Civitavecchia (Rome) to Piraeus (Athens)

For centuries, Rome ruled much of Europe, building a vast empire from the power of emperors. More than 2,500 years of history live in the city’s streets. Ancient structures recall those heady days when the cheers of 80,000 spectators roared from the Colosseum, citizens mingled in the Forum and senators asked the gods for guidance at the Pantheon. Along with the Vatican and St. Peter’s Basilica, this rich pocket of Italy is one of the world’s greatest repositories of history and civilization.

Ponza is a captivating crescent-shaped volcanic island in the Pontine Islands archipelago, located off the Tyrrhenian Sea between Rome and Naples. It is primarily a tender port visited by smaller, more boutique cruise ships, offering a more tranquil and intimate Italian island escape. The cruise experience focuses heavily on exploring the stunning coastline by boat and the charming, hilly main town, Porto.

Salerno is an Italian city located on the Gulf of Salerno. Famous for being home to the first medical university, Salerno is a great destination for anyone looking for gorgeous sea views filled with sunshine and Italian food.

Home to the Museo Regionale of Messina, known for featuring two of Caravaggio's paintings, the city is also famous for having been the capital of the ancient kingdom of Sicily.

Siracusa, known to English speakers as Syracuse, is a wonder to behold. One of the great ancient capitals of Western civilization, the city was founded in 734 BC by Greek colonists from Corinth and soon grew to rival, and even surpass, Athens in splendor and power. It became the largest, wealthiest city-state in the West and a bulwark of Greek civilization. Although Siracusa lived under tyranny, rulers such as Dionysius filled their courts with Greeks of the highest cultural stature—among them the playwrights Aeschylus and Euripides, and the philosopher Plato. The Athenians, who didn't welcome Siracusa's rise, set out to conquer Sicily, but the natives outsmarted them in what was one of the greatest military campaigns in ancient history (413 BC). The city continued to prosper until it was conquered two centuries later by the Romans.Present-day Siracusa still has some of the finest examples of Baroque art and architecture; dramatic Greek and Roman ruins; and a Duomo that's the stuff of legend—a microcosm of the city's entire history in one building. The modern city also has a wonderful, lively, Baroque old town worthy of extensive exploration, as well as pleasant piazzas, outdoor cafés and bars, and a wide assortment of excellent seafood. There are essentially two areas to explore in Siracusa: the Parco Archeologico (Archaeological Zone), on the mainland; and the island of Ortygia, the ancient city first inhabited by the Greeks, which juts out into the Ionian Sea and is connected to the mainland by two small bridges. Ortygia is becoming increasingly popular with tourists, and is starting to lose its old-fashioned charm in favor of modern boutiques.Siracusa's old nucleus of Ortygia, a compact area, is a pleasure to amble around without getting unduly tired. In contrast, mainland Siracusa is a grid of wider avenues. At the northern end of Corso Gelone, above Viale Paolo Orsi, the orderly grid gives way to the ancient quarter of Neapolis, where the sprawling Parco Archeologico is accessible from Viale Teracati (an extension of Corso Gelone). East of Viale Teracati, about a 10-minute walk from the Parco Archeologico, the district of Tyche holds the archaeological museum and the church and catacombs of San Giovanni, both off Viale Teocrito (drive or take a taxi or city bus from Ortygia). Coming from the train station, it's a 15-minute trudge to Ortygia along Via Francesco Crispi and Corso Umberto. If you're not up for that, take one of the free electric buses leaving every 10 minutes from the bus station around the corner.

Zakynthos is the largest of the Ionian Islands and is famous for its dramatic coastline, turquoise waters, and unique natural landmarks. The town is built in Venetian style and features several points of interest:

• Solomos Square (Plateia Solomou): The central square lined with neo-classical buildings, including the Byzantine Museum of Zakynthos.

• Agios Dionysios Church: A prominent seaside church dedicated to the island’s patron saint, known for its tall, Venetian-style bell tower.

• Bochali Hill: Located above the town, offering panoramic views of the harbor and the town center. It contains the ruins of the Venetian Castle.

Enter Souda Bay to land on Greece's largest island, and explore the sun-soaked charms of this fascinating land of legends, landscapes, and luxuries. Packed with beautiful beaches and rich maritime history, Souda Bay's huge natural harbor is a spectacular entrance, opening up the treasures of Crete's many well-stocked museums, rich archaeological sites, and charming Venetian fishing towns. The massive natural harbor of Souda Bay also makes the site an interesting spot for military history - with a huge NATO base here, as well as the Souda Bay War Cemetery, which honors Allied soldiers of World War II. Soak up some Mediterranean sunshine by heading straight to one of the luxurious white sand beaches - where you can recline to a soundtrack of fizzing waves, and dine with sparkling sea views stretching out before you. Explore olive groves producing golden oil, and savor the deep, fruity flavors. The island's renowned wineries, also invite you to sample lovingly-crafted Vilana grape wines. Rethymno's old town and star-shaped, seafront fortress are impressive sites to explore, or you can head to Akrotiri to discover the Arkadi Monastery's role in the Cretan resistance - and visit the site where the Greek flag was hoisted high into the sky by rebels in 1897. Crete retains its independent spirit but has gathered countless influences over its history. The island's most beautiful Venetian port - Chania - is close by, and its picturesque old town and collage of historical influences are a highlight of any trip.

Embark your ship and settle into your stateroom. Athens has been called the “birthplace of democracy.” Its legacy looms large from atop Acropolis Hill, the pinnacle of ancient Greece. This open air museum is an astonishing repository of once-mighty structures. From its colonnaded Parthenon—built more than 2,600 years ago—revered Greek philosophers like Plato and Aristotle formulated new ideas of government and debated its role in civic life to captivated audiences. Remnants of spiritual life are also here in the several temples to Athena and Zeus.